We Reviewed the Top 20 Brands to Find the Best Quality Nootropic in 2025
Discover the Top-Ranked Nootropic Supplements for 2025
The growing pursuit of enhanced memory, focus, and overall cognitive performance has propelled nootropic supplements into the spotlight. As more people seek natural ways to unlock their brain’s potential, these innovative formulations have rapidly gained attention online. Motivated by this surge in interest, we dedicated weeks to comprehensive research and testing. The result is this detailed guide, showcasing our top five nootropic supplements available in the U.S. for 2025.
Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Nootropic Supplement review article.
Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Nootropic Supplement review article.
What are Nootropic Supplements?
Nootropic supplements have emerged as natural options with the potential to boost brain performance.
Derived from sources like Bacopa, Lion’s Mane, and Ginkgo Biloba, these cognitive enhancers have been traditionally used to sharpen focus, support memory, and promote mental clarity.
Recent research is unveiling even broader benefits for overall brain health…
Nootropics May Help With:
What To Look For In A Nootropic Supplement
Choose nootropics that feature ingredients backed by research for enhancing cognitive function, memory, and focus. Look for components such as Bacopa Monnieri, Lion’s Mane Mushroom, Ginkgo Biloba, and Alpha-GPC—each supported by studies for their roles in boosting mental clarity and brain performance.*
A high-quality nootropic supplement will clearly list all active ingredients and their exact dosages. This transparency not only helps you understand what you’re taking but also allows you to compare the formulation against clinical research for optimal cognitive benefits.
Opt for nootropics manufactured in the USA, where stringent quality control measures are enforced. Additionally, select products that are independently third-party tested to confirm their purity, potency, and safety—providing you with a reliable supplement for brain health.
Trustworthy brands stand behind their nootropic formulations. Look for supplements that offer a minimum 60-day, 100% money-back guarantee. This not only reflects the manufacturer’s confidence in their product but also offers you peace of mind with your purchase.
What To Avoid
Avoid nootropic supplements that include unnecessary additives, fillers, or artificial ingredients. These extra components can dilute the effectiveness of the active ingredients and may increase the risk of unwanted side effects.
Be cautious of products that make exaggerated claims, such as promising to instantly cure cognitive decline or dramatically boost brainpower overnight. Reliable nootropics focus on supporting overall cognitive health rather than serving as miracle cures. Always consult your healthcare provider before starting any new supplement regimen.
While affordability is important, the cheapest product on the market may compromise quality. Inexpensive nootropic supplements might lack transparency in their ingredient listings or have inaccurate dosages, potentially rendering them less effective or even unsafe.
What We Looked Out For:
A comparison of the best nootropic supplements
Meo Nutrition
Onnit
Life Extension
Neuriva
Sapotax
Type
Capsule
Capsule
Capsule
Capsule
Tablet
Caffeine-free
Proprietary blends
Money back guarantee
24/7 customer service
Price point
$$
$$$
$$
$$$
$$
The Top 5 Nootropic Supplements in 2025
9.7/10
TOTAL RANKING
A+
OVERALL GRADE
PROS
- Science-backed ingredients.
- Produced in the USA at an FDA licensed facility.
- 60 day, risk free, money back guarantee.
- Recommended by doctors.
- Caffeine-free, non-GMO and sugar free.
- Promotes normal brain health and function.
- Subscription and bulk discounts offered.
- Third-party tested/certificate of analysis (COA).
- Ships from Texas.
- Over 400.000+ customers.
CONS
- Due to high demand, it may sometimes be sold out.
- Non-vegan.
After reviewing the top 20 nootropic supplements, our clear standout is the Meo Nutrition Brain Flow.
This supplement delivers exceptional value with its robust formula, featuring 40 targeted ingredients designed to support various aspects of brain function and cognition.
From enhanced memory and focus to improved mental clarity and overall cognitive health - and all that while being caffeine-free.
While Brain Flow is not vegan, it maintains a commitment to quality that mirrors all Meo Nutrition products. It is non-GMO and third-party tested, ensuring a clean, effective supplement you can trust.
We were also impressed by the fast shipping and responsive customer support—our order arrived the next day, and the team was quick to assist via chat.
In terms of cost, Brain Flow is competitively priced, making it an excellent investment in your cognitive well-being.
Manufactured in Utah and backed by GMP certification, NSF Sports approval, and UDAF Organic Certification, Meo Nutrition ensures that every batch of Brain Flow meets the highest standards of quality and safety.
Conclusion
After reviewing the top 20 nootropic supplements, our clear standout is the Meo Nutrition Brain Flow.
This supplement delivers exceptional value with its robust formula, featuring 40 targeted ingredients designed to support various aspects of brain function and cognition.
From enhanced memory and focus to improved mental clarity and overall cognitive health - and all that while being caffeine-free.
While Brain Flow is not vegan, it maintains a commitment to quality that mirrors all Meo Nutrition products. It is non-GMO and third-party tested, ensuring a clean, effective supplement you can trust.
We were also impressed by the fast shipping and responsive customer support—our order arrived the next day, and the team was quick to assist via chat.
In terms of cost, Brain Flow is competitively priced, making it an excellent investment in your cognitive well-being.
Manufactured in Utah and backed by GMP certification, NSF Sports approval, and UDAF Organic Certification, Meo Nutrition ensures that every batch of Brain Flow meets the highest standards of quality and safety.
2. ONNIT Alpha Brain Nootropic
9.0/10
TOTAL RANKING
A
OVERALL GRADE
PROS
- Scienced-backed ingredients.
- Caffeine-free.
- US-made, non-GMO.
CONS
- Expensive.
- Contains sugar (maltodextrin).
ONNIT has built a strong reputation in the nootropic space, and its Alpha Brain Nootropic is a testament to that commitment.
With science-backed ingredients, this supplement is designed to support enhanced cognitive function without the use of caffeine, making it a go-to for those looking to avoid stimulants.
Manufactured in the US with non-GMO components, Alpha Brain maintains high production standards.
That said, it's important to note a few considerations. Alpha Brain is on the pricier side, and its formulation includes maltodextrin, a form of sugar that some may prefer to avoid.
Despite these factors, if you're prioritizing a quality, well-researched nootropic, ONNIT Alpha Brain stands out as an excellent choice for boosting cognitive performance.
Conclusion
ONNIT has built a strong reputation in the nootropic space, and its Alpha Brain Nootropic is a testament to that commitment.
With science-backed ingredients, this supplement is designed to support enhanced cognitive function without the use of caffeine, making it a go-to for those looking to avoid stimulants.
Manufactured in the US with non-GMO components, Alpha Brain maintains high production standards.
That said, it's important to note a few considerations. Alpha Brain is on the pricier side, and its formulation includes maltodextrin, a form of sugar that some may prefer to avoid.
Despite these factors, if you're prioritizing a quality, well-researched nootropic, ONNIT Alpha Brain stands out as an excellent choice for boosting cognitive performance.
3. Life Extension Quick Brain
8.7/10
TOTAL RANKING
B+
OVERALL GRADE
PROS
- Free of proprietary blends.
- Gluten-free and non-GMO.
- Reasonable price.
- Caffeine-free.
CONS
- Small blend of nootropics.
- No money-back guarantee.
Life Extension's Quick Brain offers a transparent, no-nonsense approach to cognitive support.
Free of proprietary blends, this supplement clearly lists all its ingredients, ensuring you know exactly what you're taking.
It's gluten-free, non-GMO, and caffeine-free, making it a clean option for those mindful of dietary restrictions and stimulant intake.
At a reasonable price, Quick Brain provides an affordable way to support cognitive performance.
However, its formulation includes a relatively small blend of nootropics, and it doesn't come with a money-back guarantee.
Despite these considerations, if you're looking for a straightforward, budget-friendly nootropic without any hidden additives, Quick Brain is a solid choice.
Conclusion
Life Extension's Quick Brain offers a transparent, no-nonsense approach to cognitive support.
Free of proprietary blends, this supplement clearly lists all its ingredients, ensuring you know exactly what you're taking.
It's gluten-free, non-GMO, and caffeine-free, making it a clean option for those mindful of dietary restrictions and stimulant intake.
At a reasonable price, Quick Brain provides an affordable way to support cognitive performance.
However, its formulation includes a relatively small blend of nootropics, and it doesn't come with a money-back guarantee.
Despite these considerations, if you're looking for a straightforward, budget-friendly nootropic without any hidden additives, Quick Brain is a solid choice.
4. NEURIVA Plus Brain
8.2/10
TOTAL RANKING
B
OVERALL GRADE
PROS
- Free of proprietary blends.
- Decaffeinated, 100% Vegan, non-GMO.
- Made in the USA.
CONS
- Small number of nootropic inrgedients.
- No transparent testing information.
- $1.37 per capsule (one a day).
NEURIVA's Plus Brain also offers a clean, no-nonsense approach to cognitive enhancement, making it an appealing option for those seeking a straightforward, plant-based nootropic.
One of its key strengths is the absence of proprietary blends—each ingredient is clearly listed, providing transparency about what you’re consuming.
The supplement is decaffeinated, 100% vegan, and non-GMO, aligning well with consumers who prioritize clean and ethically sourced products.
On the other hand, the formula features a relatively small number of nootropic ingredients, which may not offer the same breadth of cognitive support as more comprehensive blends.
There is also a lack of transparent testing information, which might leave some users questioning the efficacy and safety validation of the product.
Furthermore, at $1.37 per capsule (with a once-daily dosage), the price point is on the higher side, which could be a consideration for those on a budget.
Conclusion
NEURIVA's Plus Brain also offers a clean, no-nonsense approach to cognitive enhancement, making it an appealing option for those seeking a straightforward, plant-based nootropic.
One of its key strengths is the absence of proprietary blends—each ingredient is clearly listed, providing transparency about what you’re consuming.
The supplement is decaffeinated, 100% vegan, and non-GMO, aligning well with consumers who prioritize clean and ethically sourced products.
On the other hand, the formula features a relatively small number of nootropic ingredients, which may not offer the same breadth of cognitive support as more comprehensive blends.
There is also a lack of transparent testing information, which might leave some users questioning the efficacy and safety validation of the product.
Furthermore, at $1.37 per capsule (with a once-daily dosage), the price point is on the higher side, which could be a consideration for those on a budget.
5. Sapotax 17-in-1 Brain Supplement
7.9/10
TOTAL RANKING
C+
OVERALL GRADE
PROS
- Affordable.
- Large blend of nootropics.
- Gluten-free, non-GMO.
CONS
- Small number of reviews.
- Limited guarantees.
- Contains caffeine.
Sapotax 17-in-1 Brain Supplement presents an attractive option for those seeking comprehensive cognitive support without breaking the bank.
Its affordable price point is paired with a robust blend of nootropics designed to enhance various aspects of brain function—from improved focus and memory to increased mental clarity.
The formula is gluten-free and non-GMO, catering to users with dietary restrictions or a preference for clean ingredients.
However, there are a few considerations. The product has a relatively small number of reviews, which may leave potential users looking for more extensive consumer feedback.
It's also important to note that the supplement contains caffeine, making it unsuitable for individuals who are sensitive to stimulants or prefer a caffeine-free option.
Conclusion
Sapotax 17-in-1 Brain Supplement presents an attractive option for those seeking comprehensive cognitive support without breaking the bank.
Its affordable price point is paired with a robust blend of nootropics designed to enhance various aspects of brain function—from improved focus and memory to increased mental clarity.
The formula is gluten-free and non-GMO, catering to users with dietary restrictions or a preference for clean ingredients.
However, there are a few considerations. The product has a relatively small number of reviews, which may leave potential users looking for more extensive consumer feedback.
It's also important to note that the supplement contains caffeine, making it unsuitable for individuals who are sensitive to stimulants or prefer a caffeine-free option.
CITATIONS
- Malík M, Tlustoš P. Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers. Plants (Basel). 2023 Mar 18;12(6):1364. doi: 10.3390/plants12061364. PMID: 36987052; PMCID: PMC10056569.
- Malík M, Tlustoš P. Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs. Nutrients. 2022 Aug 17;14(16):3367. doi: 10.3390/nu14163367. PMID: 36014874; PMCID: PMC9415189.
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022 Nov;37(6):e2852. doi: 10.1002/hup.2852. Epub 2022 Jul 19. PMID: 35851507; PMCID: PMC9787829.
- Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013 Aug;16(4):313-26. doi: 10.1089/rej.2013.1431. PMID: 23772955; PMCID: PMC3746283.
- Lee KH, Cha M, Lee BH. Neuroprotective Effect of Antioxidants in the Brain. Int J Mol Sci. 2020 Sep 28;21(19):7152. doi: 10.3390/ijms21197152. PMID: 32998277; PMCID: PMC7582347.
- Kamat CD, Gadal S, Mhatre M, Williamson KS, Pye QN, Hensley K. Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis. 2008 Nov;15(3):473-93. doi: 10.3233/jad-2008-15314. PMID: 18997301; PMCID: PMC2669703.
What You Will Learn:
- The benefits of a high quality nootropic supplement
- What to look for in a nootropic supplement
- The top 5 nootropic supplements
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Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Supplement Review has with our picks.
[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our picks.
© 2025 supplement-review.co
All Rights Reserved.