
We Reviewed the Top 20 Brands to Find the Best Quality Digestive Enzymes in 2025
Discover the Top-Ranked Multi-Enzymes Supplements for 2025

More health-conscious individuals are turning to digestive enzyme supplements to help break down proteins, fats, and carbohydrates more efficiently—especially as busy lifestyles and rich diets can strain natural enzyme production. With curiosity around multi‑enzyme formulas on the rise, we devoted several weeks to in‑depth research and hands‑on testing of the latest products. In this guide, we reveal the top 5 digestive enzyme supplements available in the U.S. for 2025.

Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Digestive Enzyme Supplement review article.

Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Digestive Enzyme Supplement review article.
What are Multi-Enzyme Supplements
Digestive enzyme supplements are blends of naturally occurring enzymes—such as amylase, protease, and lipase—designed to mimic your body’s own digestive processes. By helping break down carbohydrates, proteins, and fats into absorbable nutrients, they can support smoother digestion, reduce discomfort like bloating or gas, and improve nutrient uptake when taken alongside meals.

Digestive Enzymes May Help With:
What To Look For In A Multi-Enzyme Supplement
Choose supplements that feature a broad spectrum of digestive enzymes clinically shown to support nutrient breakdown and gut comfort. Protease aids protein digestion, amylase tackles carbohydrates, lipase assists fat processing, lactase helps with lactose, and cellulase targets plant fiber. Many formulas also include plant‑derived enzymes like bromelain and papain to round out a comprehensive digestive profile.
A reputable multi‑enzyme supplement will list each enzyme’s activity in standardized units (e.g., HUT for protease, DU for amylase, FCC units for lipase). Clear activity labeling lets you verify potency, compare products, and ensure you’re getting an efficacious dose.
Opt for supplements manufactured in U.S. facilities that adhere to Good Manufacturing Practices (GMP). Independent third‑party testing should confirm both enzyme activity and absence of contaminants, giving you confidence in purity and effectiveness.
Look for brands that back their digestive formulas with at least a 60‑day, 100% money‑back guarantee. A fair return policy demonstrates the manufacturer’s confidence and lets you assess how the enzymes work for your individual needs without risk.
What To Avoid
Steer clear of products loaded with artificial colors, flavors, or bulky fillers that do not contribute to digestive support. These extras can dilute active enzymes and may lead to digestive upset.
Beware of supplements promising to “cure” digestive disorders or “detoxify” your system. Effective enzyme blends support normal digestion and comfort—they are not a treatment for medical conditions.
While cost is important, suspiciously cheap formulas may skimp on enzyme potency or quality control. Prioritize products that transparently disclose activity units and ingredient sources over those that simply undercut the competition on price.
What We Looked Out For:
A comparison of the best multi-enzyme supplements

Meo Nutrition

Physician's CHOICE

Pure Encapsulations

THORNE

NOW Foods
Type
Capsule
Capsule
Capsule
Capsule
Capsule
With Probiotics
Third-party tested
Money back guarantee
24/7 customer service
Price point
$$
$
$$$
$$$
$
The Top 5 Multi-Enzyme Supplements in 2025


9.7/10
TOTAL RANKING
A+
OVERALL GRADE
PROS
- High-dose blend of 6 enzymes + 3 Probiotics.
- 100% vegan, potent and natural formula.
- Produced in the USA at an FDA licensed facility.
- 60 day, risk free, money back guarantee.
- Recommended by doctors.
- Subscription and bulk discounts offered.
- Third-party tested/certificate of analysis (COA).
- Ships from Texas.
- Over 400.000+ customers.
CONS
- Due to high demand, it may sometimes be sold out.
- Can only be found online.
After comparing a wide range of digestive enzyme supplements, our standout choice is Meo Nutrition Pro Enzymes.
Meo Nutrition Pro Enzymes formula delivers exceptional value and comprehensive digestive support with a robust Makzyme‑Pro™ blend standardized to 2,500 HUT per serving.
This potent enzyme complex includes fungal protease from Aspergillus oryzae, Bromelain (90 GDU), Papain (2,670 TU), fungal lipase (1,500 FIP), and fungal lactase (600 LACU), as well as Alpha Galactosidase—all formulated to support protein, fat, carbohydrate, and lactose breakdown for more comfortable digestion.*
In addition to its enzyme array, Pro Enzymes features a trio of probiotics—Lactobacillus acidophilus, L. casei, and L. plantarum—to help maintain a balanced gut microbiome and promote optimal nutrient absorption.*
This supplement is vegan, non‑GMO, and free of the top nine allergens, making it suitable for virtually any diet.
We were also impressed by Meo Nutrition’s quick next‑day shipping and their responsive customer service team, who answered our questions promptly via live chat.
Finally, Meo Nutrition manufactures all its supplements in Utah under stringent GMP protocols, with NSF certification and UDAF Organic approval, ensuring every bottle of Pro Enzymes meets the highest quality standards.


Conclusion
After comparing a wide range of digestive enzyme supplements, our standout choice is Meo Nutrition Pro Enzymes.
Meo Nutrition Pro Enzymes formula delivers exceptional value and comprehensive digestive support with a robust Makzyme‑Pro™ blend standardized to 2,500 HUT per serving.
This potent enzyme complex includes fungal protease from Aspergillus oryzae, Bromelain (90 GDU), Papain (2,670 TU), fungal lipase (1,500 FIP), and fungal lactase (600 LACU), as well as Alpha Galactosidase—all formulated to support protein, fat, carbohydrate, and lactose breakdown for more comfortable digestion.*
In addition to its enzyme array, Pro Enzymes features a trio of probiotics—Lactobacillus acidophilus, L. casei, and L. plantarum—to help maintain a balanced gut microbiome and promote optimal nutrient absorption.*
This supplement is vegan, non‑GMO, and free of the top nine allergens, making it suitable for virtually any diet.
We were also impressed by Meo Nutrition’s quick next‑day shipping and their responsive customer service team, who answered our questions promptly via live chat.
Finally, Meo Nutrition manufactures all its supplements in Utah under stringent GMP protocols, with NSF certification and UDAF Organic approval, ensuring every bottle of Pro Enzymes meets the highest quality standards.
2. Physician's CHOICE Digestive Enzymes



9.0/10
TOTAL RANKING
A
OVERALL GRADE
PROS
- Large blend of 16 enzymes.
- Money-back guarantee.
- 3rd-party lab tested.
- With probiotics.
CONS
- Proprietary blends.
- Some report constipation.
Physician’s CHOICE has earned a reputation for delivering clinically informed formulas backed by rigorous quality standards, and their Digestive Enzymes supplement exemplifies that dedication.
This comprehensive blend combines 16 different enzymes—including protease, amylase, lipase, and cellulase—with a complementary probiotic strain to support broad‑spectrum digestive function.*
Each batch undergoes third‑party laboratory testing, and the company offers a money‑back guarantee, underscoring their confidence in product purity and efficacy.
Given its extensive enzyme profile and the added benefit of probiotics, Digestive Enzymes by Physician’s CHOICE secures a leading position among digestive support supplements.
However, the use of proprietary blends means exact dosages for individual enzymes aren’t disclosed, and a small number of users have reported occasional constipation.
Overall, if you’re seeking a single supplement that covers a wide range of digestive enzymes and includes probiotics—with the peace of mind of third‑party verification and a satisfaction guarantee—Physician’s CHOICE Digestive Enzymes is a compelling choice.


Conclusion
Physician’s CHOICE has earned a reputation for delivering clinically informed formulas backed by rigorous quality standards, and their Digestive Enzymes supplement exemplifies that dedication.
This comprehensive blend combines 16 different enzymes—including protease, amylase, lipase, and cellulase—with a complementary probiotic strain to support broad‑spectrum digestive function.*
Each batch undergoes third‑party laboratory testing, and the company offers a money‑back guarantee, underscoring their confidence in product purity and efficacy.
Given its extensive enzyme profile and the added benefit of probiotics, Digestive Enzymes by Physician’s CHOICE secures a leading position among digestive support supplements.
However, the use of proprietary blends means exact dosages for individual enzymes aren’t disclosed, and a small number of users have reported occasional constipation.
Overall, if you’re seeking a single supplement that covers a wide range of digestive enzymes and includes probiotics—with the peace of mind of third‑party verification and a satisfaction guarantee—Physician’s CHOICE Digestive Enzymes is a compelling choice.
3. Pure Encapsulations Digestive Enzymes



8.7/10
TOTAL RANKING
B+
OVERALL GRADE
PROS
- Money-back guarantee.
- Sold on popular marketplaces.
- Simple & clean formula with 13 enzymes.
- Vegetarian & non-GMO.
CONS
- Expensive.
- No testing information.
Pure Encapsulations has long been respected for its commitment to hypoallergenic, research‑driven formulations, and their Digestive Enzymes supplement upholds that standard.
This carefully crafted formula combines thirteen distinct enzymes—ranging from protease and amylase to cellulase—into a simple, clean blend designed to support comprehensive digestive function.*
Sold widely through popular marketplaces and made with vegetarian, non‑GMO ingredients, it also comes with a satisfaction guarantee that underscores the brand’s confidence in its products.
Given Pure Encapsulations’ reputation for pharmaceutical‑grade purity and the supplement’s straightforward ingredient profile, Digestive Enzymes earns a prime position among enzyme blends.
However, its premium pricing may put it out of reach for budget‑minded shoppers, and there’s no publicly available third‑party testing data to independently verify potency or purity.
Overall, if you’re seeking a high‑quality, allergy‑friendly enzyme supplement and price isn’t your primary concern, Pure Encapsulations Digestive Enzymes is an excellent option.


Conclusion
Pure Encapsulations has long been respected for its commitment to hypoallergenic, research‑driven formulations, and their Digestive Enzymes supplement upholds that standard.
This carefully crafted formula combines thirteen distinct enzymes—ranging from protease and amylase to cellulase—into a simple, clean blend designed to support comprehensive digestive function.*
Sold widely through popular marketplaces and made with vegetarian, non‑GMO ingredients, it also comes with a satisfaction guarantee that underscores the brand’s confidence in its products.
Given Pure Encapsulations’ reputation for pharmaceutical‑grade purity and the supplement’s straightforward ingredient profile, Digestive Enzymes earns a prime position among enzyme blends.
However, its premium pricing may put it out of reach for budget‑minded shoppers, and there’s no publicly available third‑party testing data to independently verify potency or purity.
Overall, if you’re seeking a high‑quality, allergy‑friendly enzyme supplement and price isn’t your primary concern, Pure Encapsulations Digestive Enzymes is an excellent option.
4. THORNE - Advanced Digestive Enzymes



8.2/10
TOTAL RANKING
B
OVERALL GRADE
PROS
- Small & simple blend.
- Money-back guarantee.
- In-house lab tested.
- Made in the USA.
CONS
- Expensive.
- Limited blend.
Thorne is renowned for its rigorous scientific approach and premium-quality supplements, and their Advanced Digestive Enzymes continue this legacy.
Formulated in the USA and validated through Thorne’s in-house laboratory testing, this blend combines a targeted selection of key enzymes—such as protease, amylase, and lipase—to support efficient digestion of proteins, carbohydrates, and fats.*
Backed by a satisfaction guarantee, Thorne demonstrates confidence in both the purity and performance of this streamlined formula.
Given its trusted brand heritage, transparent testing, and convenient, minimalist enzyme profile, Advanced Digestive Enzymes earns a spot in our review for those seeking dependable digestive support.
However, its premium price point and the absence of a broader enzyme spectrum may leave some users wanting more comprehensive coverage.
Overall, if you value a small, high-quality enzyme blend from a company with proven manufacturing and testing standards—and aren’t deterred by the cost—Thorne Advanced Digestive Enzymes is an excellent choice.


Conclusion
Thorne is renowned for its rigorous scientific approach and premium-quality supplements, and their Advanced Digestive Enzymes continue this legacy.
Formulated in the USA and validated through Thorne’s in-house laboratory testing, this blend combines a targeted selection of key enzymes—such as protease, amylase, and lipase—to support efficient digestion of proteins, carbohydrates, and fats.*
Backed by a satisfaction guarantee, Thorne demonstrates confidence in both the purity and performance of this streamlined formula.
Given its trusted brand heritage, transparent testing, and convenient, minimalist enzyme profile, Advanced Digestive Enzymes earns a spot in our review for those seeking dependable digestive support.
However, its premium price point and the absence of a broader enzyme spectrum may leave some users wanting more comprehensive coverage.
Overall, if you value a small, high-quality enzyme blend from a company with proven manufacturing and testing standards—and aren’t deterred by the cost—Thorne Advanced Digestive Enzymes is an excellent choice.
5. NOW Foods Super Enzymes



7.9/10
TOTAL RANKING
C+
OVERALL GRADE
PROS
- Third-party tested.
- Affordable.
- US-made, gluten-free & non-GMO.
CONS
- No money-back guarantee.
- Non-vegan.
NOW Foods has built its reputation on delivering reliable, budget‑friendly supplements, and their Super Enzymes formula upholds this tradition.
This comprehensive digestive support blend is manufactured in the USA, gluten‑free, non‑GMO, and undergoes third‑party testing to verify both potency and purity.
Priced well below many competitors, Super Enzymes makes broad‑spectrum digestive assistance accessible to a wide audience.
Despite these strengths, the product does not come with a money‑back guarantee, and its use of bovine‑derived ingredients means it isn’t suitable for vegans.
Overall, if you’re seeking an affordable, rigorously tested enzyme supplement and don’t require a vegan formula or a satisfaction guarantee, NOW Foods Super Enzymes offers an excellent value for comprehensive digestive support.


Conclusion
NOW Foods has built its reputation on delivering reliable, budget‑friendly supplements, and their Super Enzymes formula upholds this tradition.
This comprehensive digestive support blend is manufactured in the USA, gluten‑free, non‑GMO, and undergoes third‑party testing to verify both potency and purity.
Priced well below many competitors, Super Enzymes makes broad‑spectrum digestive assistance accessible to a wide audience.
Despite these strengths, the product does not come with a money‑back guarantee, and its use of bovine‑derived ingredients means it isn’t suitable for vegans.
Overall, if you’re seeking an affordable, rigorously tested enzyme supplement and don’t require a vegan formula or a satisfaction guarantee, NOW Foods Super Enzymes offers an excellent value for comprehensive digestive support.
CITATIONS
- Ullah H, Di Minno A, Piccinocchi R, Buccato DG, De Lellis LF, Baldi A, El-Seedi HR, Khalifa SAM, Piccinocchi G, Xiao X, Sacchi R, Daglia M. Efficacy of digestive enzyme supplementation in functional dyspepsia: A monocentric, randomized, double-blind, placebo-controlled, clinical trial. Biomed Pharmacother. 2023 Dec 31;169:115858. doi: 10.1016/j.biopha.2023.115858. Epub 2023 Nov 14. PMID: 37976892.
- Rathi A, Gaonkar T, Dhar D, Kallapura G, Jadhav S. Study of amino acids absorption and gut microbiome on consumption of pea protein blended with enzymes-probiotics supplement. Front Nutr. 2024 Jan 23;11:1307734. doi: 10.3389/fnut.2024.1307734. PMID: 38321993; PMCID: PMC10844538.
- Anderson ML. A Double-Blind Clinical Study to Investigate the Effects of a Fungal Protease Enzyme System on Metabolic, Hepato-renal, and Cardiovascular Parameters Following 30 Days of Supplementation in Active, Healthy Men. Food Dig. 2013 May;4(1):19-25. doi: 10.1007/s13228-011-0016-3. Epub 2011 Dec 13. PMID: 23658598; PMCID: PMC3644185.
- Latif A, Shehzad A, Niazi S, Zahid A, Ashraf W, Iqbal MW, Rehman A, Riaz T, Aadil RM, Khan IM, Özogul F, Rocha JM, Esatbeyoglu T, Korma SA. Probiotics: mechanism of action, health benefits and their application in food industries. Front Microbiol. 2023 Aug 17;14:1216674. doi: 10.3389/fmicb.2023.1216674. Erratum in: Front Microbiol. 2024 Feb 14;15:1378225. doi: 10.3389/fmicb.2024.1378225. PMID: 37664108; PMCID: PMC10470842.
What You Will Learn:
- The benefits of a high quality digestive-enzyme supplement
- What to look for in a digestive-enzyme supplement
- The top 5 digestive-enzyme supplements

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[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Supplement Review has with our picks.

[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our picks.
© 2025 supplement-review.co
All Rights Reserved.