
We Reviewed the Top 20 Brands to Find the Best Quality Stress & Mood Support in 2025
Discover the Top-Ranked Stress & Mood Support Supplements for 2025

Feeling stressed or overwhelmed by the demands of daily life? You're not alone—many people are exploring supplements designed to naturally support mood balance and help manage everyday stress. Given this rising interest, we've dedicated several weeks to carefully researching and evaluating numerous supplements formulated for stress support and emotional wellness. In this comprehensive guide, we present the top 5 mood support supplements available in the U.S. for 2025.

Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Stress & Mood Support Supplement review article.

Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Stress & Mood Support Supplement review article.
What are Stress & Mood Support Supplements?
Stress & mood support supplements typically contain a blend of vitamins, minerals, herbs, and other natural ingredients. Common ingredients often include adaptogens like Ashwagandha, calming botanicals such as St. John's Wort, amino acids like Gamma-Aminobutyric Acid (GABA), and 5-HTP. They may work to promote a positive mood and help you relax and unwind.

Mood Support Supplements May Help With:
What To Look For In A Mood Support Supplement
Choose supplements featuring ingredients with research demonstrating support for positive mood and healthy stress management. Well‑studied options include magnesium, L‑theanine, 5‑HTP, ashwagandha, and Rhodiola rosea.*
A trustworthy product will list every active ingredient alongside its precise dosage. This clarity lets you know exactly what you’re taking and compare it to doses shown effective in clinical studies.
Opt for supplements made in the USA under strict quality‑control standards. Look for independent third‑party testing to confirm purity, potency, and safety—ensuring you get a high‑quality, reliable product.
Reputable brands back their formulas with a solid return policy. Seek out supplements offering at least a 60‑day, full money‑back guarantee—evidence of the manufacturer’s confidence and your own peace of mind when trying something new.
What To Avoid
Steer clear of products containing extra fillers, artificial colors, or preservatives. These can dilute active ingredients and raise the chance of unwanted side effects.
Beware of supplements that promise “miracle cures” or claim to treat specific disorders. Quality mood support products aim to help maintain emotional balance—not replace professional medical care. Always consult your healthcare provider before beginning any supplement regimen.
While cost matters, the cheapest products often cut corners on ingredient quality or dosage accuracy. Choosing the lowest‑priced supplement may leave you with something ineffective—or worse, unsafe.
What We Looked Out For:
A comparison of the best mood support supplements

Meo Nutrition

Thorne

NOW Foods

Happy Healthy Hippie

OLLY
Type
Capsule
Capsule
Capsule
Capsule
Softgel
Ingredients
Vitamins, botanicals & adaptogens
Vitamins, botanicals & adaptogens
Vitamins & botanicals
Botanicals & adaptogens
Adaptogens
Third-party tested
Money back guarantee
24/7 customer service
Price point
$$
$$
$
$$$
$$
The Top 5 Stress & Mood Support Supplements in 2025


9.7/10
TOTAL RANKING
A+
OVERALL GRADE
PROS
- Comprehensive blend of adaptogens, vitamins & botanicals.
- Produced in the USA at an FDA licensed facility.
- 60 day, risk free, money back guarantee.
- Recommended by doctors.
- Subscription and bulk discounts offered.
- Third-party tested/certificate of analysis (COA).
- Ships from Texas.
- Over 400.000+ customers.
CONS
- Due to high demand, it may sometimes be sold out.
- Can only be found online.
After comparing the leading mood support supplements on the market, our clear favorite is Meo Nutrition’s Inner Calm.
Its core combination of Ashwagandha root extract, Gamma‑Aminobutyric Acid (GABA), L‑Theanine, St. John's Wort, and 5‑HTP works synergistically to promote relaxation, positive mood, and restful sleep.
Inner Calm is vegan, non-GMO, and free of the top nine allergens, making it accessible to a wide array of dietary preferences and sensitivities.
At just $0.66 per capsule—or as low as $0.42 per capsule when purchased in bulk—it represents outstanding value for such a comprehensive formula.
We were equally impressed by Meo Nutrition’s commitment to service: our order arrived via next‑day shipping, and their customer support team responded promptly and knowledgeably whenever we had questions in their chat box.
Finally, all Meo Nutrition supplements are proudly manufactured in Utah under strict GMP standards, NSF Sports® approved, and UDAF Organic Certified, ensuring every bottle of Inner Calm meets rigorous quality and purity benchmarks.


Conclusion
After comparing the leading mood support supplements on the market, our clear favorite is Meo Nutrition’s Inner Calm.
Its core combination of Ashwagandha root extract, Gamma‑Aminobutyric Acid (GABA), L‑Theanine, St. John's Wort, and 5‑HTP works synergistically to promote relaxation, positive mood, and restful sleep.
Inner Calm is vegan, non-GMO, and free of the top nine allergens, making it accessible to a wide array of dietary preferences and sensitivities.
At just $0.66 per capsule—or as low as $0.42 per capsule when purchased in bulk—it represents outstanding value for such a comprehensive formula.
We were equally impressed by Meo Nutrition’s commitment to service: our order arrived via next‑day shipping, and their customer support team responded promptly and knowledgeably whenever we had questions in their chat box.
Finally, all Meo Nutrition supplements are proudly manufactured in Utah under strict GMP standards, NSF Sports® approved, and UDAF Organic Certified, ensuring every bottle of Inner Calm meets rigorous quality and purity benchmarks.
2. Thorne Stress Balance



9.0/10
TOTAL RANKING
A
OVERALL GRADE
PROS
- Blend of adaptogens, botanicsl and vitamins.
- Third-party tested.
- Money-back guarantee.
CONS
- Some reviews report increased anxiety.
Thorne is a leading company in the supplement industry, known for their quality ingredients, exceptional testing standards, and outstanding products.
Their Stress Balance formula is no exception, earning praise from both healthcare practitioners and health‑minded consumers.
Stress Balance delivers a targeted blend of adaptogens, botanicals, and vitamins—combining stress‑modulating herbs with essential micronutrients to support your body’s response to daily pressures.
Each batch is third‑party tested for potency and purity, and Thorne stands behind the formula with a money‑back guarantee.
However, Stress Balance comes with a premium price tag, and a small number of user reviews have reported increased anxiety or feelings of overstimulation.
While the 60‑day guarantee is helpful, return shipping costs are incurred when ordering directly from Thorne’s website.
Overall, Thorne’s Stress Balance is an excellent choice for those seeking a comprehensive stress‑support supplement backed by rigorous testing and a solid satisfaction policy.


Conclusion
Thorne is a leading company in the supplement industry, known for their quality ingredients, exceptional testing standards, and outstanding products.
Their Stress Balance formula is no exception, earning praise from both healthcare practitioners and health‑minded consumers.
Stress Balance delivers a targeted blend of adaptogens, botanicals, and vitamins—combining stress‑modulating herbs with essential micronutrients to support your body’s response to daily pressures.
Each batch is third‑party tested for potency and purity, and Thorne stands behind the formula with a money‑back guarantee.
However, Stress Balance comes with a premium price tag, and a small number of user reviews have reported increased anxiety or feelings of overstimulation.
While the 60‑day guarantee is helpful, return shipping costs are incurred when ordering directly from Thorne’s website.
Overall, Thorne’s Stress Balance is an excellent choice for those seeking a comprehensive stress‑support supplement backed by rigorous testing and a solid satisfaction policy.
3. NOW Foods Mood Support



8.7/10
TOTAL RANKING
B+
OVERALL GRADE
PROS
- Includes vitamins & botanicals.
- Third-party tested.
- Sold on popular marketplaces.
- Reasonable price.
CONS
- Lacks adaptoigens.
- No money-back guarantee.
- Some report discomfort.
NOW Foods Mood Support is a widely available supplement sold on major marketplaces, making it easy to pick up whether you’re shopping online or in‑store.
The formula combines a selection of mood‑supporting vitamins (including a B‑complex) with a wide range of botanical extracts to help promote emotional well‑being.
Every batch is third‑party tested to verify label accuracy and purity, and at its price point—often under $0.15 per capsule—it offers solid affordability.
One drawback is the absence of adaptogens in the blend, which means it may not provide the same stress‑modulating benefits as some competitor formulas.
There’s also no money‑back guarantee, so if you experience any discomfort, you won’t be able to return it for a refund.
Overall, NOW Foods Mood Support is a budget‑friendly choice that delivers core vitamins and botanicals for mood health, but if you’re seeking adaptogenic support or a satisfaction policy, you may want to explore other options.


Conclusion
NOW Foods Mood Support is a widely available supplement sold on major marketplaces, making it easy to pick up whether you’re shopping online or in‑store.
The formula combines a selection of mood‑supporting vitamins (including a B‑complex) with a wide range of botanical extracts to help promote emotional well‑being.
Every batch is third‑party tested to verify label accuracy and purity, and at its price point—often under $0.15 per capsule—it offers solid affordability.
One drawback is the absence of adaptogens in the blend, which means it may not provide the same stress‑modulating benefits as some competitor formulas.
There’s also no money‑back guarantee, so if you experience any discomfort, you won’t be able to return it for a refund.
Overall, NOW Foods Mood Support is a budget‑friendly choice that delivers core vitamins and botanicals for mood health, but if you’re seeking adaptogenic support or a satisfaction policy, you may want to explore other options.
4. Happy Healthy Hippie - Joy-Filled Mood Support



8.2/10
TOTAL RANKING
B
OVERALL GRADE
PROS
- Premium blend of botanicals & adaptogens.
- Supports restful sleep.
- Made in the USA.
CONS
- No money-back guarantee.
- Some report increased sleepiness.
- Expensive.
Happy Healthy Hippie’s Joy‑Filled Mood Support has quickly gained a following for its premium blend of botanicals and adaptogens, making it a go‑to for those seeking both mood uplift and nighttime calm.
The formula features clinically studied herbs like Ashwagandha and Rhodiola to help balance stress hormones, alongside botanicals such as lemon balm that are traditionally used to promote restful sleep. It’s proudly made in the USA, and each batch is crafted to deliver consistent potency.
Despite these strengths, Joy‑Filled Mood Support does carry a higher price tag than many mainstream options, and there’s no money‑back guarantee to fall back on if you’re dissatisfied.
A few users have noted that it can induce increased sleepiness during daytime hours, which suggests paying close attention to timing your doses.
Overall, Happy Healthy Hippie’s Joy‑Filled Mood Support stands out for its high‑quality ingredients and dual support for mood and sleep.


Conclusion
Happy Healthy Hippie’s Joy‑Filled Mood Support has quickly gained a following for its premium blend of botanicals and adaptogens, making it a go‑to for those seeking both mood uplift and nighttime calm.
The formula features clinically studied herbs like Ashwagandha and Rhodiola to help balance stress hormones, alongside botanicals such as lemon balm that are traditionally used to promote restful sleep. It’s proudly made in the USA, and each batch is crafted to deliver consistent potency.
Despite these strengths, Joy‑Filled Mood Support does carry a higher price tag than many mainstream options, and there’s no money‑back guarantee to fall back on if you’re dissatisfied.
A few users have noted that it can induce increased sleepiness during daytime hours, which suggests paying close attention to timing your doses.
Overall, Happy Healthy Hippie’s Joy‑Filled Mood Support stands out for its high‑quality ingredients and dual support for mood and sleep.
5. OLLY Goodbye Stress



7.9/10
TOTAL RANKING
C+
OVERALL GRADE
PROS
- High bioavailability.
- Quick release capsules.
- Gluten-free & non-GMO.
CONS
- Small blend of adaptogens and amino acids.
- Some reviews consider it overpriced.
- Limited testing and money-back guarantees.
OLLY is a well‑known brand in the lifestyle supplement space, prized for its approachable formulas and eye‑catching packaging.
Their Goodbye Stress capsules simplify stress support with a focused blend of ashwagandha, lemon balm, L‑theanine, and GABA—ingredients chosen for their rapid calming effects.
The formula’s quick‑release capsule design enhances absorption, helping you feel the benefits of these key ingredients sooner. Goodbye Stress is also gluten‑free and non‑GMO, aligning with common dietary needs even though it isn’t vegan.
However, the narrowly scoped ingredient profile means you miss out on the broader adaptogen and botanical spectrum found in other products.
Some users feel the price is high for just four actives, and OLLY doesn’t back Goodbye Stress with extensive third‑party testing or a money‑back guarantee.
Overall, if you want a streamlined, fast‑acting stress relief formula and don’t mind paying a premium for convenience, OLLY Goodbye Stress could be an effective, no‑frills option.


Conclusion
OLLY is a well‑known brand in the lifestyle supplement space, prized for its approachable formulas and eye‑catching packaging.
Their Goodbye Stress capsules simplify stress support with a focused blend of ashwagandha, lemon balm, L‑theanine, and GABA—ingredients chosen for their rapid calming effects.
The formula’s quick‑release capsule design enhances absorption, helping you feel the benefits of these key ingredients sooner. Goodbye Stress is also gluten‑free and non‑GMO, aligning with common dietary needs even though it isn’t vegan.
However, the narrowly scoped ingredient profile means you miss out on the broader adaptogen and botanical spectrum found in other products.
Some users feel the price is high for just four actives, and OLLY doesn’t back Goodbye Stress with extensive third‑party testing or a money‑back guarantee.
Overall, if you want a streamlined, fast‑acting stress relief formula and don’t mind paying a premium for convenience, OLLY Goodbye Stress could be an effective, no‑frills option.
CITATIONS
- Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. J Affect Disord. 2017 Mar 1;210:211-221. doi: 10.1016/j.jad.2016.12.048. Epub 2017 Jan 3. PMID: 28064110.
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022 Nov;37(6):e2852. doi: 10.1002/hup.2852. Epub 2022 Jul 19. PMID: 35851507; PMCID: PMC9787829.
- Brimson JM, Brimson S, Prasanth MI, Thitilertdecha P, Malar DS, Tencomnao T. The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data. Sci Rep. 2021 Jan 12;11(1):596. doi: 10.1038/s41598-020-80045-2. PMID: 33436817; PMCID: PMC7803732.
- Baba Y, Inagaki S, Nakagawa S, Kaneko T, Kobayashi M, Takihara T. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study. J Med Food. 2021 Apr;24(4):333-341. doi: 10.1089/jmf.2020.4803. Epub 2021 Mar 22. PMID: 33751906; PMCID: PMC8080935.
- Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS One. 2021 Sep 24;16(9):e0257843. doi: 10.1371/journal.pone.0257843. PMID: 34559859; PMCID: PMC8462692.
What You Will Learn:
- The benefits of a high quality mood & stress support*
- What to look for in a mood & stress support*
- The top 5 mood & stress support* supplements

© 2025 supplement-review.co
All Rights Reserved.
[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Supplement Review has with our picks.

[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our picks.
© 2025 supplement-review.co
All Rights Reserved.

