Top 5 Alpha Lipoic Acid Supplements in 2025
Last Updated: January 20, 2025
In the last few months, we've received dozens of emails asking us to review the supplement alpha-lipoic acid, which has recently taken the internet by storm due to the number of people with neuropathy and diabetes who have been sharing online. So, over the past few weeks, we have researched and put together this article for you, in which we list our top 5 Alpha Lipoic Acid supplements available in the U.S.
Before we look at our top 5 list, let's answer a few of your most common questions around the populare alpha lipoic acid supplement.
What is alpha-lipoic acid? Alpha-lipoic acid (or lipoic acid) assists in converting glucose into energy (see What It Is). A healthy body naturally produces enough alpha-lipoic acid but supplementation may help in certain situations.
What does alpha-lipoic acid do? Alpha-lipoic acid supplements may modestly improve insulin sensitivity and blood sugar control, as well as reduce symptoms of peripheral neuropathy in people with type 2 diabetes. It may also modestly increase weight and fat loss when combined with a low-calorie diet (see What It Does).
What's the right dose of alpha-lipoic acid? The typical dose used in treating diabetes, peripheral neuropathy associated with diabetes, and cardiac autonomic neuropathy is 200 to 400 mg, taken 3 times daily (for a total daily dose ranging from 600 mg to 1,200 mg). For weight loss, 100 mg alpha-lipoic acid (taken three times per day with meals), along with a reduced-calorie diet, has shown some benefit. For use as a general antioxidant, a lower dose (20 to 50 mg daily) is commonly recommended (although there is no evidence this offers any health benefit). You may be able to halve the dose when using the R-isomer-only form (see What to Consider When Using).
What are the side-effects of alpha-lipoic acid? Side effects of alpha lipoic acid such as skin rash and nausea have been reported. Alpha lipoic acid may also contribute to acid reflux, as it is an acid. It may also cause a strong urine odor. Because alpha-lipoic acid may help control blood sugar in diabetics, adjustments may be needed to anti-diabetic medication when using alpha-lipoic acid. Alpha-lipoic acid may interfere with thyroid function, medication and diagnostic tests. Although rare, alpha lipoic acid may cause insulin autoimmunity (see Concerns and Cautions).
If you have any further qusestions about the alpha lipoic acid feel free to send us an email at supplementreview.co@gmail.com. Now let's look at our favorite alpha lipoic acid product from Meo Nutrition and why we ranked is as the winner of this years review.
1. Alpha Lipoic Acid 650 mg
By Meo Nutrition [1]
147+ 5 Star Reviews
RATING
A+
147 Reviews
RATING
A+
SUMMARY:
Meo Nutrition is a trusted brand due to their priority for quality and research. Their brand is backed by medical doctors and nutritionists, ensuring only the highest quality products get to the market, and their alpha lipoic acid is not any different. It contains 650 mg of alpha lipoic acid per serving and is sold at a reasonable price.
Summary:
Meo Nutrition is a trusted brand due to their priority for quality and research. Their brand is backed by medical doctors and nutritionists, ensuring only the highest quality products get to the market, and their alpha lipoic acid is not any different. It contains 650 mg of alpha lipoic acid per serving and is sold at a reasonable price.
PROS:
- Free of Top 9 Allergens, Gluten Free, Non-GMO, Vegan and Made in the USA
- 650 mg of alpha lipoic acid per serving
- Labratory tested
- 60 day money back guarantee
- Backed by medical doctors and nutritionists
CONS:
- Can only be bought on their website
- Often sold out
Overview
After reviewing the top 20 alpha lipoic acid supplements, our favorite by far was the Meo Nutrition alpha lipoic acid supplement.
It boasts a clean and potent formula containing 650 mg of alpha lipoic acid without any additional ingredients. However, many competitors offer the same formula, so what set Meo's supplement apart was their 60-day satisfaction guarantee, their quick shipping (we received it the next day), and their responsive customer service when tested.
In addition to its pure and potent ingredients, this berberine supplement is also incredibly well-priced, coming in at just $0.56 per capsule—or as low as $0.49 per capsule when purchased in bulk.
Finally, they offer a fair, 60-day, risk-free, money-back guarantee. Most companies won’t do this, which demonstrates how much they stand behind their products. Overall, Meo Nutrition is our top pick.
Conclusion:
After reviewing the top 20 alpha lipoic acid supplements, our favorite by far was the Meo Nutrition alpha lipoic acid supplement.
It boasts a clean and potent formula containing 650 mg of alpha lipoic acid without any additional ingredients. However, many competitors offer the same formula, so what set Meo's supplement apart was their 60-day satisfaction guarantee, their quick shipping (we received it the next day), and their responsive customer service when tested.
In addition to its pure and potent ingredients, this berberine supplement is also incredibly well-priced, coming in at just $0.56 per capsule—or as low as $0.49 per capsule when purchased in bulk.
Finally, they offer a fair, 60-day, risk-free, money-back guarantee. Most companies won’t do this, which demonstrates how much they stand behind their products. Overall, Meo Nutrition is our top pick.
*The results are based on supplement-review.co's ranking system and do not necessarily reflect typical results from using these products. Visit the products' websites for more information.
2. Thorne Alpha-Lipoic Acid
By Thorne
479+ 4.7 Star Reviews
RATING
A+
153 Reviews
RATING
A+
SUMMARY:
Thorne is another excellent company that is a long-term thinker and has been making excellent supplements for years. Their product is great but comes at a slightly higher price than Meo Nutrition and has only 300 mg per serving compared to 650 mg for this year's winner.
Summary:
Thorne is another excellent company that is a long-term thinker and has been making excellent supplements for years. Their product is great but comes at a slightly higher price than Meo Nutrition and has only 300 mg per serving compared to 650 mg for this year's winner.
PROS:
- Dairy free, gluten free, soy free and no artificial flavors.
- 60 Capsules of 300 mg alpha lipoic acid
- 4 rounds of testing
- Trusted by the olympic team
CONS:
- Lacking money back guarantee
- Higher price and lower amount of alpha lipoic acid in each bottle
REVIEW:
Thorne's Alpha Lipoic Acid supplement, specifically their Thiocid-300 product, stands out in the crowded field of health supplements for several compelling reasons. Firstly, Thorne, as a brand, is renowned for its commitment to purity, quality, and scientific research, ensuring that their products deliver on their promises. The Thiocid-300 Alpha Lipoic Acid supplement is no exception, offering 300 mg of alpha lipoic acid per serving. This dosage, while lower than some competitors, is precisely calibrated for optimal absorption and effectiveness, based on Thorne's rigorous research standards.
Although it comes at a premium price compared to some alternatives, the investment in Thorne's product can be justified by the brand's reputable manufacturing processes, including third-party testing and production in facilities that adhere to the highest standards. Furthermore, Thorne's product is designed to support a wide range of bodily functions, from promoting healthy metabolic processes to acting as a powerful antioxidant.
For those who prioritize quality and efficacy in their dietary supplements, Thorne's Thiocid-300 offers a potent and scientifically backed option, despite its higher price point and lower dosage compared to the previous year's winner.
Conclusion:
Thorne's Alpha Lipoic Acid supplement, specifically their Thiocid-300 product, stands out in the crowded field of health supplements for several compelling reasons. Firstly, Thorne, as a brand, is renowned for its commitment to purity, quality, and scientific research, ensuring that their products deliver on their promises. The Thiocid-300 Alpha Lipoic Acid supplement is no exception, offering 300 mg of alpha lipoic acid per serving. This dosage, while lower than some competitors, is precisely calibrated for optimal absorption and effectiveness, based on Thorne's rigorous research standards.
Although it comes at a premium price compared to some alternatives, the investment in Thorne's product can be justified by the brand's reputable manufacturing processes, including third-party testing and production in facilities that adhere to the highest standards. Furthermore, Thorne's product is designed to support a wide range of bodily functions, from promoting healthy metabolic processes to acting as a powerful antioxidant.
For those who prioritize quality and efficacy in their dietary supplements, Thorne's Thiocid-300 offers a potent and scientifically backed option, despite its higher price point and lower dosage compared to the previous year's winner.
*The results are based on supplement-review.co's ranking system and do not necessarily reflect typical results from using these products. Visit the products' websites for more information.
3. Pure Encapsulations Alpha Lipoic Acid 600 mg
By Pure Encapsulations
479+ 4.7 Star Reviews
RATING
A+
153 Reviews
RATING
A+
SUMMARY:
Pure Encapsulations is a top-tier choice for individuals seeking high-quality supplements. They are committed to offering products emphasized on purity and safety. Each capsule is packed with 600mg of alpha lipoic acid at a premium price.
Summary:
Pure Encapsulations is a top-tier choice for individuals seeking high-quality supplements. They are committed to offering products emphasized on purity and safety. Each capsule is packed with 600mg of alpha lipoic acid at a premium price.
PROS:
- Free from common allergens
- 60 Capsules of 600 mg alpha lipoic acid
- Prioritizes purity and efficacy
CONS:
- Costly
REVIEW:
Pure Encapsulations' Alpha Lipoic Acid supplement is a top-tier choice for individuals seeking a high-quality, lipid-soluble antioxidant. Crafted with hypoallergenic ingredients, this product stands out for its commitment to purity and safety, catering especially to those with sensitive systems or specific dietary needs. Each capsule provides a potent dose of alpha lipoic acid, designed to support a range of bodily functions including glucose metabolism and neural health.
What sets Pure Encapsulations apart is their rigorous standards for quality control, ensuring that each batch is free from common allergens, GMOs, and unnecessary additives. This focus on purity makes it an ideal option for those who are cautious about the supplements they consume.
Although priced at a premium, the value is evident in the product's superior formulation and the peace of mind it offers through its clean label. For anyone prioritizing purity and efficacy in their supplement regimen, Pure Encapsulations' Alpha Lipoic Acid is a distinguished choice.
Conclusion:
Pure Encapsulations' Alpha Lipoic Acid supplement is a top-tier choice for individuals seeking a high-quality, lipid-soluble antioxidant. Crafted with hypoallergenic ingredients, this product stands out for its commitment to purity and safety, catering especially to those with sensitive systems or specific dietary needs. Each capsule provides a potent dose of alpha lipoic acid, designed to support a range of bodily functions including glucose metabolism and neural health.
What sets Pure Encapsulations apart is their rigorous standards for quality control, ensuring that each batch is free from common allergens, GMOs, and unnecessary additives. This focus on purity makes it an ideal option for those who are cautious about the supplements they consume.
Although priced at a premium, the value is evident in the product's superior formulation and the peace of mind it offers through its clean label. For anyone prioritizing purity and efficacy in their supplement regimen, Pure Encapsulations' Alpha Lipoic Acid is a distinguished choice.
*The results are based on supplement-review.co's ranking system and do not necessarily reflect typical results from using these products. Visit the products' websites for more information.
4. Doctor's Best Alpha-Lipoic Acid 600mg
By Doctor's Best
479+ 4.7 Star Reviews
RATING
A+
153 Reviews
RANK
A+
SUMMARY:
Doctor's Best Alpha-Lipoic Acid is tailored to meet the needs of a wide audience. They emphasizes the importance of quality and safety in their products, making this supplement an excellent choice for those looking to enhance their antioxidant intake and support metabolic health.
Summary:
Doctor's Best Alpha-Lipoic Acid is tailored to meet the needs of a wide audience. They emphasizes the importance of quality and safety in their products, making this supplement an excellent choice for those looking to enhance their antioxidant intake and support metabolic health.
PROS:
- Potent dose of 600 mg alpha lipoic acid per serving
- Accommodates various dietary restrictions and preferences
- Good choice for those looking to support metabolic health
CONS:
- Lacking money back guarantee
Conclusion:
Doctor's Best Alpha-Lipoic Acid 600 offers a potent dose of 600 mg per serving, crafted to support the maintenance of blood sugar levels and promote overall health.
This supplement is tailored to meet the needs of a wide audience, being non-GMO, gluten-free, vegan, and soy-free, thus accommodating various dietary restrictions and preferences. The inclusion of 180 veggie caps per bottle provides a generous supply, ensuring long-term support for users.
Doctor's Best emphasizes the importance of quality and safety in their products, making this supplement an excellent choice for those looking to enhance their antioxidant intake and support metabolic health. The commitment to accessibility and health maintenance makes Doctor's Best Alpha-Lipoic Acid 600 a valuable addition to one's wellness regimen.
Conclusion:
Doctor's Best Alpha-Lipoic Acid 600 offers a potent dose of 600 mg per serving, crafted to support the maintenance of blood sugar levels and promote overall health.
This supplement is tailored to meet the needs of a wide audience, being non-GMO, gluten-free, vegan, and soy-free, thus accommodating various dietary restrictions and preferences. The inclusion of 180 veggie caps per bottle provides a generous supply, ensuring long-term support for users.
Doctor's Best emphasizes the importance of quality and safety in their products, making this supplement an excellent choice for those looking to enhance their antioxidant intake and support metabolic health. The commitment to accessibility and health maintenance makes Doctor's Best Alpha-Lipoic Acid 600 a valuable addition to one's wellness regimen.
*The results are based on supplement-review.co's ranking system and do not necessarily reflect typical results from using these products. Visit the products' websites for more information.
5. NOW Supplements Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine®
By NOW Supplements
479+ 4.7 Star Reviews
RATING
A+
153 Reviews
RANK
A+
SUMMARY:
NOW Supplements offers a unique blend designed to bolster antioxidant activity and support overall health. The addition of Grape Seed Extract and Bioperine increases absorption and efficacy, making this product stand out in the market for those focused on cardiovascular, neural and metabolic health.
Summary:
NOW Supplements offers a unique blend designed to bolster antioxidant activity and support overall health. The addition of Grape Seed Extract and Bioperine increases absorption and efficacy, making this product stand out in the market for those focused on cardiovascular, neural and metabolic health.
PROS:
- Includes Grape Seed Extract and Bioperine
- 60 Capsules of 600 mg alpha lipoic acid
- GMP quality-assured
CONS:
- Lacking money back guarantee
- Higher price and lower amount of alpha lipoic acid in each bottle
Conclusion:
NOW Supplements' Alpha Lipoic Acid 600 mg with Grape Seed Extract and Bioperine® offers a unique blend designed to bolster antioxidant activity and support overall health. This formulation not only promotes the production of glutathione but also enhances the antioxidant functions of vitamins C and E. The addition of Grape Seed Extract and Bioperine® increases absorption and efficacy, making this product stand out in the market for those focused on cardiovascular, neural, and metabolic health.
With strict adherence to Kosher, Dairy-Free, Egg-Free, Gluten-Free, Nut-Free, Soy-Free, Vegan, and Vegetarian standards, this supplement caters to a wide range of dietary needs and preferences. The GMP Quality Assured certification underscores NOW's commitment to the highest manufacturing standards, ensuring product safety, potency, and formulation integrity.
It's important to note the caution regarding the potential for melting or damage if exposed to heat or sunlight, highlighting the need for proper storage and handling upon delivery. This attention to quality and detail makes NOW Supplements' Alpha Lipoic Acid an excellent choice for those seeking comprehensive antioxidant support.
Conclusion:
NOW Supplements' Alpha Lipoic Acid 600 mg with Grape Seed Extract and Bioperine® offers a unique blend designed to bolster antioxidant activity and support overall health. This formulation not only promotes the production of glutathione but also enhances the antioxidant functions of vitamins C and E. The addition of Grape Seed Extract and Bioperine® increases absorption and efficacy, making this product stand out in the market for those focused on cardiovascular, neural, and metabolic health.
With strict adherence to Kosher, Dairy-Free, Egg-Free, Gluten-Free, Nut-Free, Soy-Free, Vegan, and Vegetarian standards, this supplement caters to a wide range of dietary needs and preferences. The GMP Quality Assured certification underscores NOW's commitment to the highest manufacturing standards, ensuring product safety, potency, and formulation integrity.
It's important to note the caution regarding the potential for melting or damage if exposed to heat or sunlight, highlighting the need for proper storage and handling upon delivery. This attention to quality and detail makes NOW Supplements' Alpha Lipoic Acid an excellent choice for those seeking comprehensive antioxidant support.
*The results are based on supplement-review.co's ranking system and do not necessarily reflect typical results from using these products. Visit the products' websites for more information.
Our Favorite
1. Alpha Lipoic Acid 650mg
By Meo Nutrition [1]
147+ 5 Star Reviews
RATING
A+
Summary
Meo Nutrition is a trusted brand due to their priority for quality and research. Their brand is backed by medical doctors and nutritionists ensuring only the highest quality products get to the market, and their alpha lipoic acid is not any different. It contains 650 mg of alpha lipoic acid per serving and is sold at a reasonable price.
154 Reviews
RANK
A+
Summary:
Meo Nutrition is a trusted brand due to their priority for quality and research. Their brand is backed by medical doctors and nutritionists, ensuring only the highest quality products get to the market, and their alpha lipoic acid is not any different. It contains 650 mg of alpha lipoic acid per serving and is sold at a reasonable price.
How we ranked them:
Ingredient Quality and Purity: We prioritized the sourcing and purity of alpha lipoic acid (ALA) in our evaluation. Meo Nutrition secured the top position by sourcing premium-grade ALA from trusted suppliers and ensuring purity through rigorous testing. Thorne followed closely with a commitment to sourcing high-quality ALA from reputable sources.
Bioavailability and Absorption Enhancement: The bioavailability of ALA is crucial for its effectiveness in the body. Doctor's Best and Meo Nutrition excelled in this aspect by incorporating advanced absorption-enhancing technologies into their formulations, ensuring maximum bioavailability of ALA. Pure Encapsulations also demonstrated a commitment to bioavailability through innovative delivery systems.
Transparency and Manufacturing Practices: We assessed the transparency of manufacturing processes and adherence to quality standards in our evaluation. Meo Nutrition stood out for its transparent practices and adherence to strict manufacturing standards, providing consumers with confidence in product quality. NOW Supplements also demonstrated transparency and commitment to quality manufacturing practices.
Additional Ingredients and Formulation: Some ALA supplements may include additional ingredients to enhance their effectiveness or address specific health needs. NOW Supplements and Meo Nutrition offered comprehensive formulations with additional ingredients that complemented the benefits of ALA. Thorne also provided formulations with carefully selected additional ingredients, catering to diverse consumer preferences and health goals.
Customer Reviews and Satisfaction: Customer feedback and satisfaction played a significant role in our ranking process. Meo Nutrition received positive reviews for its ALA supplement, with customers praising its effectiveness and quality. Thorne, Pure Encapsulations, Doctor's Best, and NOW Supplements also received favorable reviews, indicating satisfaction among users. Customer feedback provided valuable insights into the real-world effectiveness and quality of the ALA supplements, contributing to their rankings.
In our comprehensive evaluation, Meo Nutrition emerged as the top choice for its superior ingredient quality, bioavailability, transparency, formulation, and customer satisfaction. Thorne, Pure Encapsulations, Doctor's Best, and NOW Supplements also earned their positions in the top five for their commendable efforts in these criteria, ensuring consumers have access to high-quality ALA supplements tailored to their needs.
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