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We reviewed the top 20 weight loss supplements of 2025 and found one that actually worked
Discover the Top-Ranked Weight Loss Supplements in 2025
At our company, we have reviewed over 34 different types of supplements, but none have been more requested than this one: What is the best weight loss supplement, and which ones actually work?
After dozens of emails requesting our review, we finally delivered. We spent the past 8 months researching and conducting tests to compile our list of the top weight loss supplements on the market for 2025.
Our initial hypothesis was far from correct, and we were surprised to find that the best-performing weight loss supplement was Meo Nutrition Berberine—a simple product without any of the filler ingredients often found in popular fat burners.
Last year, a few studies emerged showing the powerful effects of berberine on weight loss. These included blindfolded studies and clinical research, which revealed that taking berberine daily had a direct correlation with weight loss, appetite suppression, and even activation of AMPK, which regulates metabolism and can boost fat burning.
So, without further introduction, let’s dive into our review and show you what we found and how the top-rated supplement, Meo Nutrition, can help you on your weight loss journey.
Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise is highlighted in our Top 5 Berberine Supplement review article.
Elisabeth Larsen, Research Specialist
With extensive experience in the field of supplements, Elisabeth stands out as a leading author and researcher. Her expertise shines in our review article on the top 5 weight loss supplements.
The best-performing weight loss product contains only berberine. Here’s why it works...
Berberine is a natural botanical that just last year changed the weight loss industry when a 12-week study showed that taking only 500 mg of berberine daily resulted in 5 pounds of weight loss and an average of 3.5% less body fat.
Berberine has since increased in popularity, and many users report that it helps curb their cravings for unhealthy foods, making it easier to lose weight without changing their daily habits.
How berberine can help you loose weight
Berberine activates AMP-activated protein kinase (AMPK), which regulates metabolism and can increase fat burning [2,3]
Research suggests berberine can inhibit the growth and development of fat cells at the molecular level [1]*
Some studies indicate berberine may have direct appetite-suppressing effects, though the exact mechanism is not fully understood
What To Look For In A Berberine Supplement
If you are on a diet and find it hard to suppress unhealthy food cravings, then an effective appetite suppressant will be your savior. No matter how difficult it is for you to suppress your appetite, it can do wonders.
Simply put, your metabolism is all of the chemical processes that convert carbohydrates, proteins, and fats from your food into the energy that your cells need to function. By increasing your metabolism, you’ll have more energy and lose more weight, even when you aren’t exercising.
Most health experts will tell you that energy levels are a combination of genetics, sleep, and exercise. Oftentimes those who struggle with weight problems don’t have the energy and motivation to exercise. An effective fat burner should give you an energy boost to help you stay active and power through exercises.
We want to wake up each morning, ready to get up and go. A fat burner that boosts your mood can help ward off emotional eating and sleeping disorders while helping with motivation to give you the drive you need to succeed.
What To Avoid
As many of you probably already know – too much caffeine can cause nervousness, jitters, anxiety and issues with tolerance. An effective fat burner should use natural ingredients that work well in-conjunction with caffeine to provide you with an energy boost.
This can be a real issue with unknown and/or new brands. Always use a fat burner that contains all-natural ingredients. Lookout for products that sneak in dangerous ingredients that can put your health in jeopardy.
As mentioned above, unknown and/or new brands can be dangerous. These companies like to make outlandish claims because they don’t plan on sticking around. Lately we’ve seen countless Keto Products popup in Google from various unknown brands, we recommend steering clear of these products. We haven’t been able to confirm the ingredients or effectiveness of any of these products.
The Top 5 Weight Loss Supplements in 2025
1. Meo Nutrition Berberine Supplement
9.7/10
TOTAL RANKING
A+
OVERALL GRADE
PROS
- Clean, potent formula with scientifically-backed ingredients.
- Manufactured in the USA in an FDA-registered facility.
- 90-day money-back guarantee for customer satisfaction.
- Supports increased metabolism and fat burning.
- Helps suppress appetite for easier calorie control.
- Subscription options available for convenience and savings.
- Third-party tested for purity and potency.
- Free of artificial colors, flavors, and preservatives.
- Transparent labeling with no proprietary blends.
- Positive reviews from over 75,000 customers.
CONS
- Due to high demand, it may sometimes be sold out.
- Can only be found online.
We began by reviewing the types of weight loss supplements that have proven effective. After narrowing it down to berberine, we then examined the top berberine brands to find the best option. The clear standout was Meo Nutrition’s berberine supplement.
Numerous studies have linked berberine to weight loss benefits. To summarize two of the most significant scientific studies: one 12-week study showed that taking 500 mg daily led to an average weight loss of 5 pounds and a 3.6% reduction in body fat. Another review of 12 studies highlighted significant decreases in body weight, BMI, and waist circumference when berberine was taken daily.
In our search for the top berberine brand, we evaluated the best-selling options from the past four years, comparing their ingredients, customer feedback, lab test results, and more. Meo Nutrition stood out due to several key factors. We appreciated that they manufacture locally in Utah and use third-party testing to verify the potency of each capsule. Their formula contains a pure 1200 mg of berberine—no fillers. Unlike many weight loss supplements loaded with caffeine and minimal active ingredients, Meo Nutrition's berberine is formulated to be as effective as possible, even if it increases manufacturing costs.
Beyond their commitment to science and quality, we were also impressed with Meo Nutrition’s quick shipping and excellent customer support. We received our order the next day, and their customer service team was prompt and helpful via chat.
In terms of price, Meo Nutrition’s berberine supplement is competitively priced at just $0.66 per capsule, or as low as $0.49 when purchased in bulk. It has received excellent reviews, with users noting it’s easy to consume and produces noticeable results.
Finally, Meo Nutrition manufactures all their supplements in Utah, holding GMP certification, NSF sports approval, and UDAF Organic certification, ensuring quality in every product.
Conclusion
We began by reviewing the types of weight loss supplements that have proven effective. After narrowing it down to berberine, we then examined the top berberine brands to find the best option. The clear standout was Meo Nutrition’s berberine supplement.
Numerous studies have linked berberine to weight loss benefits. To summarize two of the most significant scientific studies: one 12-week study showed that taking 500 mg daily led to an average weight loss of 5 pounds and a 3.6% reduction in body fat. Another review of 12 studies highlighted significant decreases in body weight, BMI, and waist circumference when berberine was taken daily.
In our search for the top berberine brand, we evaluated the best-selling options from the past four years, comparing their ingredients, customer feedback, lab test results, and more. Meo Nutrition stood out due to several key factors. We appreciated that they manufacture locally in Utah and use third-party testing to verify the potency of each capsule. Their formula contains a pure 1200 mg of berberine—no fillers. Unlike many weight loss supplements loaded with caffeine and minimal active ingredients, Meo Nutrition's berberine is formulated to be as effective as possible, even if it increases manufacturing costs.
Beyond their commitment to science and quality, we were also impressed with Meo Nutrition’s quick shipping and excellent customer support. We received our order the next day, and their customer service team was prompt and helpful via chat.
In terms of price, Meo Nutrition’s berberine supplement is competitively priced at just $0.66 per capsule, or as low as $0.49 when purchased in bulk. It has received excellent reviews, with users noting it’s easy to consume and produces noticeable results.
Finally, Meo Nutrition manufactures all their supplements in Utah, holding GMP certification, NSF sports approval, and UDAF Organic certification, ensuring quality in every product.
2. Fitspresso
9.5/10
TOTAL RANKING
C+
OVERALL GRADE
PROS
- Contains natural caffeine for enhanced energy and focus.
- Includes green tea extract for metabolism support.
- Formulated with L-theanine to promote relaxation without drowsiness.
- Made with organic, non-GMO ingredients.
CONS
- Costly at 50$ per bottle.
- 1000 mg berberine compared to 1200 mg.
- May cause jitters or anxiety in caffeine-sensitive individuals.
- Not suitable for those avoiding caffeine or stimulants.
- Limited flavor options available.
- Potential interactions with certain medications due to caffeine content.
Conclusion
Fitspresso is a fat burner supplement created by FitSpresso Inc. Its primary goal is to increase your metabolic rate for more effective fat loss.
FitSpresso came in 2nd because it contains Capsicum Annum, L-Carnitine and Chromium Picolinate. We think these are staples in creating a modest energy boost to assist in fat loss, unfortunately it lacks the unique ingredients that our #1 pick Meo Nutrition contains, Berberine.
FitSpresso also contains Panax Ginseng which is meant to act as an oxidative reducer, but based on our research, this ingredient lacks the research to prove its effectiveness. Similarly, it
contains Silybum Marianum and Lagerstroemia Speciosa which we can’t find enough science to support its effectiveness. FitSpresso is a decent brand in the fitness industry mainly because its products don’t contain fillers and additives, which we of course appreciate.
A few drawbacks to consider:
We prefer if FitSpresso didn’t have Silybum Marianum and Lagerstroemia Speciosa. There’s not enough science to support these ingredients.
FitSpresso has a multitude of ingredients without much science to back them and is in the the upper limit of what we like in a fat burner. Users should research each ingredient before taking them or consult with a physician.
Conclusion
Fitspresso is a fat burner supplement created by FitSpresso Inc. Its primary goal is to increase your metabolic rate for more effective fat loss.
FitSpresso came in 2nd because it contains Capsicum Annum, L-Carnitine and Chromium Picolinate. We think these are staples in creating a modest energy boost to assist in fat loss, unfortunately it lacks the unique ingredients that our #1 pick Meo Nutrition contains, Berberine.
FitSpresso also contains Panax Ginseng which is meant to act as an oxidative reducer, but based on our research, this ingredient lacks the research to prove its effectiveness. Similarly, it
contains Silybum Marianum and Lagerstroemia Speciosa which we can’t find enough science to support its effectiveness. FitSpresso is a decent brand in the fitness industry mainly because its products don’t contain fillers and additives, which we of course appreciate.
A few drawbacks to consider:
We prefer if FitSpresso didn’t have Silybum Marianum and Lagerstroemia Speciosa. There’s not enough science to support these ingredients.
FitSpresso has a multitude of ingredients without much science to back them and is in the the upper limit of what we like in a fat burner. Users should research each ingredient before taking them or consult with a physician.
3. Jacked Factory Burn-XT
9.5/10
TOTAL RANKING
C-
OVERALL GRADE
PROS
- Contains caffeine and green tea extract for energy and metabolism boost
- Includes Acetyl L-Carnitine for potential fat burning support
- Uses Capsimax cayenne pepper extract as a thermogenic
CONS
- High amounts of caffeine.
- No money-back guarantee.
Conclusion
Jacked Factory Burn-XT is a popular fat burner supplement aimed at increasing metabolic rate and supporting fat loss. It contains several key ingredients commonly found in fat burners:
Jacked Factory has a solid reputation in the supplement industry. Burn-XT receives generally positive reviews on retail sites, averaging around 3.8-4 stars. However, the company doesn't use an independent review service, so authenticity of all reviews can't be verified.
While Burn-XT contains some evidence-backed ingredients like caffeine and green tea extract, the efficacy of some components (Acetyl L-Carnitine, cayenne extract) is less certain. The high caffeine content may be a concern for stimulant-sensitive individuals.
Overall, it's a decent option but may not stand out compared to some other leading fat burners on the market.
Conclusion
Jacked Factory Burn-XT is a popular fat burner supplement aimed at increasing metabolic rate and supporting fat loss. It contains several key ingredients commonly found in fat burners:
Jacked Factory has a solid reputation in the supplement industry. Burn-XT receives generally positive reviews on retail sites, averaging around 3.8-4 stars. However, the company doesn't use an independent review service, so authenticity of all reviews can't be verified.
While Burn-XT contains some evidence-backed ingredients like caffeine and green tea extract, the efficacy of some components (Acetyl L-Carnitine, cayenne extract) is less certain. The high caffeine content may be a concern for stimulant-sensitive individuals.
Overall, it's a decent option but may not stand out compared to some other leading fat burners on the market.
4. Quadralean Thermo
9.5/10
TOTAL RANKING
D
OVERALL GRADE
PROS
- Thermogenic formula designed to boost metabolism and fat burning.
- Contains a blend of natural ingredients for energy and focus.
CONS
- No transparent testing information.
- May cause side effects like anxiety or jitteriness due to stimulants.
- Can be costly compared to other fat burners.
- Limited flavor options for users who prefer variety.
Conclusion
RSP QuadraLean Thermo Fat Burner came in 4th in our ranking, it contains high quality Caffeine and Green Tea Extract, which are the two staples we look for in a fat burner.
QuadraLean also includes many ingredients such as Conjugated Linoleic Acid, Acetyl L Carnitine, Grains of Paradise and Cayenne Pepper Fruit Extract. Unfortunately, there just isn't enough science to support the effectiveness of these ingredients in-terms of fat loss.
RSP Nutrition is a well-known company that has been around for well over a decade - that combined with the high quality caffeine and Green Tea Extract is the primary reason we decided to include it in this list. We just wish they included more scientifically proven ingredients in their formula.
QuadraLean doesn’t use an independent review service like TrustSpot, (in the case of our #1 Meo Nutrition berberine) so we have to take their reviews with a grain of salt as we don’t know if they’re truly authentic from verified buyers. But we see most reviews are between 3.7 and 4.0 stars.
A few drawbacks to consider:
QuadraLean has 200 mg of caffeine, this is the upper limit of what we recommend. Users might experience jitters, anxiety and/or a crash after taking it.
QuadraLean contains Conjugated Linoleic Acid, (CLA) there has been some controversy surrounding the safety and efficacy of consuming CLA supplements.
QuadraLean has some fillers we don’t care for, specifically, Gelatine, Dicalcium Phosphate, Plant Cellulose, Magnesium Stearate and Silicon Dioxide.
Conclusion
RSP QuadraLean Thermo Fat Burner came in 4th in our ranking, it contains high quality Caffeine and Green Tea Extract, which are the two staples we look for in a fat burner.
QuadraLean also includes many ingredients such as Conjugated Linoleic Acid, Acetyl L Carnitine, Grains of Paradise and Cayenne Pepper Fruit Extract. Unfortunately, there just isn't enough science to support the effectiveness of these ingredients in-terms of fat loss.
RSP Nutrition is a well-known company that has been around for well over a decade - that combined with the high quality caffeine and Green Tea Extract is the primary reason we decided to include it in this list. We just wish they included more scientifically proven ingredients in their formula.
QuadraLean doesn’t use an independent review service like TrustSpot, (in the case of our #1 Meo Nutrition berberine) so we have to take their reviews with a grain of salt as we don’t know if they’re truly authentic from verified buyers. But we see most reviews are between 3.7 and 4.0 stars.
A few drawbacks to consider:
QuadraLean has 200 mg of caffeine, this is the upper limit of what we recommend. Users might experience jitters, anxiety and/or a crash after taking it.
QuadraLean contains Conjugated Linoleic Acid, (CLA) there has been some controversy surrounding the safety and efficacy of consuming CLA supplements.
QuadraLean has some fillers we don’t care for, specifically, Gelatine, Dicalcium Phosphate, Plant Cellulose, Magnesium Stearate and Silicon Dioxide.
5. SuperHD Ultimate Fat Burner
9.5/10
TOTAL RANKING
F+
OVERALL GRADE
PROS
- Powerful thermogenic formula with 400mg of caffeine per serving[7].
- Combines fast-acting and extended-release caffeine technology[4].
- Contains clinically tested ingredients like DygloFit, Capros, and Capsimax Cayenne[4].
CONS
- May cause significant side effects like jitters, anxiety, and rapid heart rate[1][2].
- Can lead to excessive sweating and flushing[1].
- May cause nausea and stomach discomfort in some users[2].
- High caffeine content may interfere with sleep if taken later in the day[1].
- Unlikely to provide significant weight loss benefits on its own[3].
- More expensive than regular SuperHD, with limited additional benefits[3].
Cellucor SuperHD Ultimate came in 5th in our ranking, it contains high quality Caffeine, Green Tea Extract and L-Tyrosine.
Cellucor SuperHD also contains several other ingredients such as Amla Fruit Extract, Dandelion Root Extract and Capsimax Cayenne.
Unfortunately, we can’t find enough science to support the effectiveness of these additional ingredients.
Cellucor is made by NutraBolt which has been around since 2002, that combined with the fact it includes high quality Caffeine, Green Tea Extract and L-Tyrosine is why we included it in this list.
A few drawbacks to consider:
Cellucor SuperHD Ultimate has 400 mg of caffeine, this is why we ranked it last in our list.
We recommend you steer clear of this product If you’re sensitive to caffeine. Many users complain of jitters, anxiety and crashes.
Cellucor SuperHD Ultimate contains, which can cause an unhealthy increase in blood pressure.
Cellucor SuperHD Ultimate came in 5th in our ranking, it contains high quality Caffeine, Green Tea Extract and L-Tyrosine.
Cellucor SuperHD also contains several other ingredients such as Amla Fruit Extract, Dandelion Root Extract and Capsimax Cayenne.
Unfortunately, we can’t find enough science to support the effectiveness of these additional ingredients.
Cellucor is made by NutraBolt which has been around since 2002, that combined with the fact it includes high quality Caffeine, Green Tea Extract and L-Tyrosine is why we included it in this list.
A few drawbacks to consider:
Cellucor SuperHD Ultimate has 400 mg of caffeine, this is why we ranked it last in our list.
We recommend you steer clear of this product If you’re sensitive to caffeine. Many users complain of jitters, anxiety and crashes.
Cellucor SuperHD Ultimate contains, which can cause an unhealthy increase in blood pressure.
CITATIONS
[1] https://www.naturalmedicinejournal.com/journal/2012-12/clinical-applications-berberine
[2] https://medlineplus.gov/ency/article/002423.htm
[3] Ye Yu, Liu Xiufen, Wu Ninghua, Han Yanqi, Wang Jiawen, Yu Yuandong, Chen Qingjie, Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Frontiers in Pharmacology, 12, 2021, DOI: 10.3389/fphar.2021.653887, ISSN: 1663-9812, https://www.frontiersin.org/article/10.3389/fphar.2021.653887.
[4] Jacob Schor, Clinical Applications for Berberine, Natural Medicine Journal, March 24, 2014, https://www.naturalmedicinejournal.com/journal/clinical-applications-berberine.
[5] Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004;10(12):1344-1351.
[6] 26 (12): 3215–3218. https://doi.org/10.2337/diacare.26.12.3215
[7] https://pubmed.ncbi.nlm.nih.gov/22842630/
[8] https://pubmed.ncbi.nlm.nih.gov/24174332/
[9] https://diabetes.diabetesjournals.org/content/55/8/2256.full
[10] https://pubmed.ncbi.nlm.nih.gov/10409121/
[11] https://pubmed.ncbi.nlm.nih.gov/8557660/
[12] https://pubmed.ncbi.nlm.nih.gov/25607236/
[13] https://pubmed.ncbi.nlm.nih.gov/18442638/
[14] https://pubmed.ncbi.nlm.nih.gov/25861268/
[15] https://pubmed.ncbi.nlm.nih.gov/18397984/
[16] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478874/
[17] https://www.sciencedirect.com/science/article/abs/pii/S0944711312001870
[18] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310165/
[19] https://pubmed.ncbi.nlm.nih.gov/12812656/
[20] https://pubmed.ncbi.nlm.nih.gov/17202835/
[21] https://pubmed.ncbi.nlm.nih.gov/23512497/
[22] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832145/
[23] https://pubmed.ncbi.nlm.nih.gov/17341006/
[24] https://pubmed.ncbi.nlm.nih.gov/18355829/
[25] https://pubmed.ncbi.nlm.nih.gov/19687008/
[26] https://www.hindawi.com/journals/ecam/2014/289264/
[27] https://pubmed.ncbi.nlm.nih.gov/21110076/
[28] https://pubmed.ncbi.nlm.nih.gov/23087140/
[29] https://www.hindawi.com/journals/ecam/2013/308134/
[30] https://pubmed.ncbi.nlm.nih.gov/12860219/
What You Will Learn:
- The benefits of a high quality berberine supplement
- What to look for in a berberine supplement
- The top 5 berberine supplements
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[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Supplement Review has with our picks.
[1] This website is owned and operated by Cosari® and Meo Nutrition® brands.
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Note: The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a healthcare provider. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Results do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.
Trademarks utilized on our website belong to their respective owners and no implied or expressed endorsement of our website or services is intended. Rankings can be affected by the relationship Smarter Choices has with our picks.
© 2025 supplement-review.co
All Rights Reserved.